![]() ![]() Any statistical software with general mixed model can be employed for fitting the advanced meta-analysis models. gave an overview of packages available for DTA meta-analysis and briefly discussed their strength and weakness ( 6). In the recent book of Diagnostic Meta-Analysis, Doebler et al. bivariate model ( 3) and HSROC model ( 4), which also allow for both within and between study variability.Īlthough HSROC and bivariate models are commonly regarded as the best practice and recommended in the Cochrane Handbook ( 5), suboptimal methods are still frequently used in studies performing meta-analysis of diagnostic accuracy, since they are widely implemented in software and packages and more accessible than the preferred ones. Since then, the statistical methods evolved from simply following the approaches used for intervention meta-analyses to the summary ROC (sROC) model (also known as Moses-Littenberg model) which takes in to account the threshold effect ( 2), and then to more advanced models, i.e. It has been almost 30 years since the publication of the first meta-analysis of diagnostic test accuracy (DTA) ( 1). Received: Accepted: 17 June 2019 Published: 18 June 2019. Keywords: Diagnostic test meta-analysis HSROC bivariate model systematic review ![]()
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